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Treatment strategy changed in 2003 due to HIPS experience of limited therapeutic gains and equivocal support for IT therapy in the literature
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The bitter and sweet taste predominate with a cooling effect to reduce acid and also cool the liver, small intestine, and pancreas
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Prior to initiating treatment, a baseline ANC must be ≥1500/L for the general population, and ≥1000/L for patients w/ documented benign ethnic neutropenia (BEN)
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In these instances, reducing the dose of Sinemet gradually over time may reduce the chances of having these problems.
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